Nanoparticle PBPK model

버전 1.0.0.0 (974 KB) 작성자: MathWorks SimBiology Team
SimBiology model and code to perform CI and NCA analyses, and optimization using parallel computing.

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업데이트 날짜: 2017/11/21

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This package contains a physiologically-based pharmacokinetic (PBPK) model, based on a publication by Dong et al. The accompanying code can be used to:
* Calculate confidence intervals on parameter estimates and model predictions (SimBiology functions: sbioparameterci, sbiopredictionci)
* Perform noncompartmental analysis (NCA) on PK datasets, as well as model predictions to obtain clinically relevant parameters (SimBiology function: sbionca)
* Illustrate justifications for using parallel computing such as dealing with out-of-memory simulations and increasing performance by introducing MATLAB functions and how they work in conjunction with SimBiology (MATLAB functions: datastore, parfor, mapreduce)
This model and code were also discussed in the following webinar:
http://www.rosaandco.com/webinars/2017/enabling-qsp-and-pk-pd-workflows-using-simbiology-and-matlab-whats-new
Reference:
Model based on:
"Elucidating the in vivo fate of nanocrystals using a physiologically based pharmacokinetic model: a case study with the anticancer agent SNX-2112”
Dong D et al.
International Journal of Nanomedicine, 2015 Volume 10, 2521-2535.

인용 양식

MathWorks SimBiology Team (2022). Nanoparticle PBPK model (https://www.mathworks.com/matlabcentral/fileexchange/64988-nanoparticle-pbpk-model), MATLAB Central File Exchange. 검색됨 .

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개발 환경: R2017b
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