Adding Axon and Dendrites to the Hodgkin Huxley Equation

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Kelsey
Kelsey 2013년 10월 9일
편집: Kelsey 2013년 10월 9일
I am very new to Matlab, and I need some help:
In my neural engineering course we are modeling a neuron using the Hodgkin Huxley equation.
My code so far is as follows:
function [t,S] = HHModel_Synapse_Multiple(Tmax,InputCurrent)
Yinit=[-78.87 0.034 0.716 0.26 0 0]; % Initial V, m, h, n, slow, fst
Tsyn=Tmax/4; %Time of the Synaptic Input
StimInt=10; %Stimulation Interval
N=10;
[t,S]=ode15s(@HH_Equations,[0 Tsyn],Yinit,[],InputCurrent);
for i=1:N
Sinit=S(end,:);
Sinit(5)=Sinit(5)+1;
Sinit(6)=Sinit(6)+1;
[t2,S2]=ode15s(@HH_Equations,[Tsyn+(i-1)*StimInt Tsyn+i*StimInt],Sinit,[],InputCurrent);
t=[t;t2];
S=[S;S2];
end
Sinit=S(end,:);
[t2,S2]=ode15s(@HH_Equations,[Tsyn+N*StimInt Tmax],Sinit,[],InputCurrent);
t=[t;t2]; S=[S;S2];
plot(t,S(:,1));
title('Membrane Voltage During an Action Potential');
legend('Voltage');
xlabel('Time (ms)');
ylabel('Voltage (mV)');
plot(t,S(:,2:4));
title('State Change During an Action Potential');
legend('m','h','n');
xlabel('Time (ms)');
ylabel('Voltage (mV)');
figure,plot(t,S(:,5:6));
legend('slow','fast');
xlabel('Time (ms)');
ylabel('Voltage (mV)');
function dSdt=HH_Equations(t,S,InputCurrent)
V=S(1);
m=S(2);
h=S(3);
n=S(4);
slow=S(5);
fst=S(6);
%Constants
Cm=1;
gNa=120;
gK=36;
gL=0.3;
gsyn=0.3;
ENa=78.2;
EK=-107.1;
EL=-49.0;
ESyn=0;
slow_tau=6;
fst_tau=2;
IL=gL*(V-EL);
IK=gK*n^4*(V-EK);
INa=gNa*m^3*h*(V-ENa);
Isyn=gsyn*(slow-fst)*(V-ESyn);
dVdt=(-1./Cm)*(IL+IK+INa+Isyn-InputCurrent);
% Alpha Equations
am=-0.1*((V+35)/(exp(-0.1*(V+35))-1));
ah=0.07*exp(-0.05*(V+60));
an=(-0.01*(V+50))/(exp(-0.1*(V+50))-1);
% Beta Equations
bm=4.0*exp((-V-60)/18);
bh=1./(1+exp(-0.1*(V+30)));
bn=0.125*exp(0.0125*(-V-60));
minf=am./(am+bm);
hinf=ah./(ah+bh);
ninf=an./(an+bn);
mtau=1./(am+bm);
htau=1./(ah+bh);
ntau=1./(an+bn);
dmdt=(minf-m)/mtau;
dhdt=(hinf-h)/htau;
dndt=(ninf-n)/ntau;
dslowdt=-slow/slow_tau;
dfstdt=-fst/fst_tau;
dSdt=[dVdt; dmdt; dhdt; dndt; dslowdt; dfstdt];
end
end
This models a neuron with multiple synaptic inputs.
I need to add in axonal and dendritic inputs, but have no idea where to start.
Any help would be greatly appreciated!

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