most time-consuming lines are self-time

I did the profile of the code, and it seems the most time-consuming lines are self-time (as attached). At this case, may I know what is a right way to reduce the running time?

Thank you.

[Adam Danz]

You have almost 2 million calls to the first line of code listed and at least a million calls to the 2nd and 3rd lines. You must be doing something in a loop which could be evaluated for simplicity. A very fast function that consumes 50ms run 1 million times would accrue to nearly 14 hours. Looking at this screenshot doesn't provide much information as to how your code is structured.

As for reducing overhead time, see this comment which discusses the tradeoff of reducing overhead and potentially reducing readability.