Transit Compartments with Simbiology
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Do you have a good example in Simbiology for me modify the built-in PK models that would create 3 transit compartments prior to absorption.
Basically, I would like to create a one-compartmental PK model with 3 transit compartments and then the standard Ka parameter with first order dosing. I then want to do the same for a 2-compartmental PK model with 3 transit compartments prior to absorption.
Example 1: V, CL, Ka, MTT and Example 2: Vc, CL, Q, Vp, MTT
I attempted to use the gPKPDSim package and thought to use the standard Simbiology interface instead.
Andy
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Arthur Goldsipe
2018년 3월 30일
Have you seen the documentation example Estimate Pharmacokinetic Parameters Using SimBiology Desktop? It walks you through selecting a PK model from the built-in library within SimBiology. You should see that there are several options for 3-compartment models. See if any of those are a good starting point for you.
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