How to do Bayesian Parameter Estimation using Optimization in Simbiology

Hello Matlab Community, I have a one-compartment pharmacokinetic model with the following parameters: Ka=0.8 (1/Hour), CL=26 (Liters/Hour), Vd=947 (Liters).

I am administering is 10mg every 24-hours 14-days = 336-hours.

What I would like to do is to add in a trough plasma concentration at 14-days of 40ng/mL.

What I would like to see if Simbiology can do is to estimate the Clearance Rate (CL) alone by keeping the Ka and Vd fixed at time=336hours and concentration=40ng/mL.

I can do this manually, by adjusting the Clearance Rate parameter, but I was looking to see if this may be automated to fit the data-point or concentration at time point 336hours of 40ng/mL. Thus, time=336, concentration=40ng/mL.

Thanks for your help.

Answer 1

[Arthur Goldsipe]

The SimBiology documentation describes different ways to estimate parameters in a model. Does that help?

Answer 2

[Andy]

Hi Arthur, Of course this helps. I suppose I will run the fit data task and then I may convert that process to a matlab script. Thanks for that. I am glad to have these Matlab Answers pages.

Thanks again.