Any ideas how i can reduce the time effort?

   design=[0.6250 0.8750; 0.2500 0.7500; 0.3750 0.1250; 0.8750 0.3750; 0.1250 0.6250; 0 0; 0.5000 0.5000; 0.7500 0.2500; 0.6875 0.0625; 0.0625 0.8125; 0.1875 0.6875; 0.3125 0.3125; 0.4375 0.9375; 0.5625 0.5625; 0.9375 0.1875; 0.8125 0.4375;]       
  v=16;
  A=2;
  m=2
dm=2;
    summ=0
               for i=1:v
                 for j=1:v
                  if j==A, 
                      continue
                  end
                   for k=1:m
                    if k==dm 
                     ddii=((design(i,k)-design(j,k))^2);
                     summ=summ+ddii; 
                     else
                     ddii=((design(A,k)-design(j,k))^2);
                     summ=summ+ddii;                                  
                    end
                   end
                   ddcc(j,i,:)=[j i summ];
                   summ=0;
                 end
                 cc(i,:)=min(nonzeros(ddcc(:,i,3))); 
                end

Comments: v is an integer lets say 16. A is an integer ( any number from 1 to 16 or v). Design is a matrix, if v=16 we can say that is a 16 by 2 matrix (16 rows 2 columns), the matrix contains only positive numbers between 0 and 1 (for example 0, 0.025,0.975,0.523). Trying to vectorize the calculation in order to reduce time significantly.

Thank you in advance.

[per isakson]

Modify the code so it's possible to run it and provide sample input data.

[Dennis_Pana]

Try the code now. Thank you for your effort.