Dear Dr. W. Kurt,
I apologize for the delayed response to your query. I recently came across this question and wanted to provide you with the information you requested. Thank you for your understanding.
After reading the problem statement, came to know that you are trying to perform FPGA-in-the-loop over JTAG interface via "Hardware Setup Application". Here, you are seeing this error "Failed to initialize the RTIOStream library" in the error message window under "Test Connection" button.
At the same time, there's an error message printed at the MATLAB console as mentioned below:
In case of Windows machine with JTAG interface:
"Failed to open Digilent JTAG cable: Failed to load shared library dmgr.dll"
Solution: Install the Xilinx Vivado cable drivers which can be available under the Vivado installation path as mentioned below:
"<Vivado Install Dir>\data\xicom\cable_drivers\nt64\digilent\install_digilent.exe"
In case of Linux machine with JTAG interface:
"Failed to open Digilent JTAG cable: Failed to load shared library libdmgr.so"
Solution: Install "Digilent Adept 2 Runtime" as provided in the link below:
I hope this will resolve your issue.
Thanks,
Heman, P