TREMBLE and TEM analysis

Quantification of ligand binding with positron emission tomography (PET)

True equilibrium bolus estimation (TREMBLE) and transient equilibrium bolus estimation (TEM) are two kinetic models that offer quantification of PET ligand binding at transient equilibrium. This GUI enables user-friendly analysis using time-activity curves from brain and plasma as input and computes bound ligand quantity and BP_ND as outcome.

References to the models:
Wong, D., Sølling, T., Yokoi, F. & Gjedde, A. Quantification of extracellular dopamine release in schizophrenia and
cocaine use by means of TREMBLE. Quant. Funct. Brain Imaging with Positron Emiss. Tomogr. 463–468 (1998).

Farde, L. et al. D2 dopamine receptors in neuroleptic-naive schizophrenic patients: a positron emission tomography study with [11C] raclopride. Arch. Gen. Psychiatry 47, 213–219 (1990).