LCS

Logical clustering suite with graphical user interface.

This is the **standalone version of the Logical Clustering Suite (v1.34) for Mac PCs**. Its installation requires download of MATLAB runtime (free) as wrapper.

- The Logical Clustering Suite (LCS) clusters gene expression profiles or similar data by permutated logical gating according to their “Ideal Phenotypes” (IPs), which are defined by all possible experimental outcomes.

- Logical clustering conceptually differs from K-means-, SOM, DBSCAN and alike clustering methods that cluster gene expression profiles just according to their mutual similarity without taking the experimental groups into account.

- When just comparing two experimental groups, logical clustering simplifies to something like DESeq2 with only two possible IPs, 0 1 for upregulation & 1 0 for downregulation. Thus, methods like DESeq2, may be conceptualized as a special instance of logical clustering.

- In summary, logical clustering assumes that the locations & number of **all experimentally meaningful cluster centers are given** by the experimental design. Gene expression profiles more similar to one IP than to all the other IPs, form a logical cluster.

- Logical clustering by simple (=logic) gene correlation analysis (sGCA) was introduced in Ma Y, Hui KL, Gelashvili Z, Niethammer P. Oxoeicosanoid signaling mediates early antimicrobial defense in zebrafish. Cell Rep. 2023 Jan 31;42(1):111974. doi: 10.1016/j.celrep.2022.111974. Epub 2023 Jan 10. PMID: 36640321; PMCID: PMC9973399. Please cite if you are using LCS.

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