How to get rid of "Integration Tolerance Not Met"?

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Victoria Miller
Victoria Miller 2021년 4월 6일
답변: Arthur Goldsipe 2021년 4월 6일
I'm trying to run a simulation of a repressilator in E. coli and get the error message above. How would you recommend I fix this issue? I have already tried messing with the simulation settings, but no luck. Thanks so much.

답변 (1개)

Arthur Goldsipe
Arthur Goldsipe 2021년 4월 6일
If you simulate from the command line, you should see a warning that infinite or NaN (not-a-number) values occur during the simulation. (In R2021a you should also see these warnings in the SimBiology Model Analyzer app.)
This typically indicates a modeling error. I suggest decreasing the simulation time to something shorter and inspecting the results to make sure they make sense. I see that the value of "LacI mRNA" becomes negative after the first time step. And if I look at the reactions involving this species, the reactions rates don't look physically meaningful to me: "LacI mRNA" is consumed even when its concentration is 0.

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