What is the best way to reference a massive (8gb) data set?

I have an 8GB CSV file containing the holdings data of different mutual funds at different dates. I.e. each row in the file is a unique combination of a stock, a mutual fund that owns the stock, and a reference date. Each row also contains information such as the dollar value of that specific stock owned by the fund. I'd like to perform different calculations using this data, like the number of funds that have >x% of their money in a specific stock on a specific date, or the number of funds that increased their holdings in a stock over a certain period. etc.

What would be the best way to store and reference the data for these purposes?