Cardiac electrical activities are varying in both space and time. Human heart consists of a fractal network of muscle cells, Purkinje fibers, arteries and veins. Whole-heart modeling of electrical wave conduction and propagation involves a greater level of complexity. Our previous work developed a computer model of the anatomically realistic heart and simulated the electrical conduction with the use of cellular automata and parallel computing. However, simplistic assumptions and rules limit its ability to provide an accurate approximation of real-world dynamics on the complex heart surface, due to sensitive dependence of nonlinear dynamical systems on initial conditions. In this paper, we propose new reaction-diffusion methods and pattern recognition tools to simulate and model spatiotemporal dynamics of electrical wave conduction and propagation on the complex heart surface, which include (i) whole heart model; (ii) 2D isometric graphing of 3D heart geometry; (iii) reaction diffusion modeling of electrical waves in 2D graph, and (iv) spatiotemporal pattern recognition. Experimental results show that the proposed numerical solution has strong potentials to model the space-time dynamics of electrical wave conduction in the whole heart, thereby achieving a better understanding of disease-altered cardiac mechanisms.
% Authors: Yun Chen and Hui Yang
% The Pennsylvania State University
% 310 Leohard Building, University Park, PA
% Email: firstname.lastname@example.org
% If you find this toolbox useful, please cite the following papers:
%  Y. Chen and H. Yang, Numerical simulation and pattern characterization of
% nonlinear spatiotemporal dynamics on fractal surfaces for the whole-heart modeling
% applications,European Physical Journal B, DOI: 10.1140/epjb/e2016-60960-6
%  H. Yang, Y. Chen, and F. M. Leonelli, “Whole Heart Modeling – Spatiotemporal
% Dynamics of Electrical Wave Conduction and Propagation,” Proceedings of 2016
% IEEE Engineering in Medicine and Biology Society Conference (EMBC),
% August 16-20, 2016, Orlando, FL, United States.
Hui Yang (2020). Simulating spatiotemporal dynamics in the whole heart (https://www.mathworks.com/matlabcentral/fileexchange/78194-simulating-spatiotemporal-dynamics-in-the-whole-heart), MATLAB Central File Exchange. Retrieved .
Chen, Yun, and Hui Yang. “Numerical Simulation and Pattern Characterization of Nonlinear Spatiotemporal Dynamics on Fractal Surfaces for the Whole-Heart Modeling Applications.” The European Physical Journal B, vol. 89, no. 8, Springer Science and Business Media LLC, Aug. 2016, doi:10.1140/epjb/e2016-60960-6.
Yang, Hui, et al. “Whole Heart Modeling — Spatiotemporal Dynamics of Electrical Wave Conduction and Propagation.” 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), IEEE, 2016, doi:10.1109/embc.2016.7591990.
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