Partest

The test calculate the performance of a clinical test based on the Bayes theorem

Syntax: PARTEST(X,ALPHA)
Input:
X is the following 2x2 matrix. [true positive false positive; false negative true negative];
ALPHA - significance level for confidence intervals (default = 0.05).

Outputs:
- Prevalence
- Sensibility
- Specificity
- False positive and negative proportions
- False discovery and discovery rates
- Youden's Index and Number Needed to Diagnose (NDD)
- Positive predictivity
- Positive Likelihood Ratio
- Negative predictivity
- Negative Likelihood Ratio
- Predictive Summary Index (PSI) and Number Needed to Screen (NNS)
- Test Accuracy
- Mis-classification Rate
- F-Measure
- Test bias
- Error odds ratio
- Diagnostic odds ratio
- Discriminant Power

Example:

x=[731 270;78 1500]
Calling on Matlab the function: partest(x)
Answer is:

DIAGNOSTIC TEST PERFORMANCE PARAMETERS

Prevalence: 31.4% (29.6% - 33.2%)

Sensitivity (probability that test is positive on unhealthy subject): 90.4% (89.1% - 91.5%) False negative proportion: 9.6% (8.5% - 10.9%) False discovery rate: 27.0% (25.3% - 28.7%)

Specificity (probability that test is negative on healthy subject): 84.7% (83.3% - 86.1%) False positive proportion: 15.3% (13.9% - 16.7%) False omission rate: 4.9% (4.2% - 5.9%)

Youden's Index (a perfect test would have a Youden's index of +1): 0.7510 Number Needed to Diagnose (NND): 1.33 Around 14 persons need to be tested to return 10 positive tests for the presence of disease

Precision or Predictivity of positive test (probability that a subject is unhealthy when test is positive): 73.0% (71.3% - 74.7%) Positive Likelihood Ratio: 5.9 (5.7 - 6.2) Moderate increase in possibility of disease presence

Predictivity of negative test (probability that a subject is healthy when test is negative): 95.1% (94.1% - 95.8%) Negative Likelihood Ratio: 0.1138 (0.1094 - 0.1183) Moderate increase in possibility of disease absence

Predictive Summary Index: 0.6808 Number Needed to Screen (NNS): 1.47 Around 15 persons need to be screened to avoid 10 events (i.e. death) for the presence of disease

Accuracy or Potency: 86.5% (85.1% - 87.8%) Mis-classification Rate: 13.5% (12.2% - 14.9%) F-measure: 80.8% (79.2% - 82.3%)

Test bias: 1.2373 (0.9474 - 1.6160) Test overestimates the phenomenon Error odds ratio: 1.6869 (1.2916 - 2.2032) Diagnostic odds ratio: 52.0655 (39.8649 - 68.0002)1.0968 Discriminant Power: 2.2 A test with a discriminant value of 1 is not effective in discriminating between affected and unaffected individuals. A test with a discriminant value of 3 is effective in discriminating between affected and unaffected individuals.

Created by Giuseppe Cardillo
[e-mail]

To cite this file, this would be an appropriate format: Cardillo G. (2006). Clinical test performance: the performance of a clinical test based on the Bayes theorem. http://www.mathworks.com/matlabcentral/fileexchange/12705