how can i register and overlay two binary maps that are not perfectly identical or register two images with some variability

I have two retinal images of the eye. First is collected by the fundus camera (direct retina photography 'jpg') and one created as a combination of cross-sectional images from the OCT (3D scan in en-face view). I have logical mask that outlines vasculature of both images and I'm trying to overlap the two images for further processing with extraction of coordinates.

I have tried the registration of fundus and OCT image as well as registration of the binary maps but no success. I have also tried to re-size the images to match or crop just the area of interest in the upper images and no luck as well.

registered=imregister(fundusmap3,ONHbinary2,'similarity',optimizer,metric);

any help or advice will be really appreciated.